Global Research Journal of Public Health and Epidemiology

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Hepatic and Post-Hepatic Enzyme Activitiea in Pump Attendants in Aba Metropolis

Ikpeazu, V.O, Offiah, S.A.U, 1Chikezie J, Chigbu L.N, Onwubiko D, Ekenjoku, A.J, Chinyere, Nwaezenna O.M. and Igboh N.M.


Corresponding author:     Ikpeazu VO . :Received: 25/7/2022 | Accepted: 27/7/.2022 |                        Published:28/7/2022 

Abstract: The present study was carried out to evaluate possible changes in liver enzyme activities in petrol attendants exposed to petrol fumes. The study was carried out on 50 petrol attendants from different petrol stations in Aba, Abia State Nigeria and with a corresponding 50 apparently healthy adults who were not exposed to petrol or its fumes as control subjects. All the subjects involved in this study were between  25 to 50 years and also  served as  the petrol attendants for at least two years , Aspartate Transaminases (AST), Alanine Transaminases (ALT) and Alkaline phosphatase (ALP) activities were determined to monitor  for the presence of liver impairment. Serum was obtained from the blood collected from the test and control subjects. Data obtained were analyzed using Statistical Package for Social Sciences (SPSS version 25) and one-way analysis of variance (ANOVA), student t test and expressed as Mean standard deviation. Significant level for the analysis was set at P-value equal to or less than 0.05 (P-0.05) which was considered as being statistically significant. The result  of the study showed that serum AST, ALT and ALP activities in the petrol attendants were significantly higher (P=<0.05) when compared with the control and it was more prominent in test subjects who have been exposed for more than four years. The results  from the study therefore showed  that long time  exposure or inhalation of petrol fumes is associated with increase in liver enzyme .This may  aid early detection of liver   derangement and help prevent subsequent liver dis order 


Keywords: Transaminases , Alanine Transaminases , Alkaline phosphatase , Petrol attendants,  and Petrol fumes