Abstract

 

Accepted 2nd January, 2019.

 

Cefazolin is a semisynthetic broad-spectrum first-generation cephalosporin antibiotic useful for the treatment of a number of both Gram-positive and Gram-negative bacterial infections. The objective of this research work was to evaluate the impact of the Consciousness Energy Healing Treatment (the Trivedi Effect®) on the physicochemical, and thermal properties of cefazolin sodium powder using modern analytical techniques. Cefazolin powder sample was divided into two parts. One part of the sample was considered as a control sample (no Biofield Energy Treatment was provided), while the other part of the sample was received the Consciousness Energy Healing Treatment remotely by a renowned Biofield Energy Healer, Dahryn Trivedi and termed as a treated sample. The particle size values in the treated cefazolin sodium were decreased by 5.98%(d10), 3.55%(d50), 6.66%(d90), and 5.89%{D(4,3)}; hence, the specific surface area increased by 4.54% compared to the control sample. The latent heat of evaporation and decomposition was significantly altered by 57.32% and -24.39% in the treated sample compared with the control sample. The total weight loss was significantly decreased by 68.92% and the residue amount was significantly increased by 519.64% in the treated cefazolin sodium sample compared with the control sample. The maximum thermal degradation temperature of the 1st and 2nd peaks of the treated sample was increased by 8.72% and 1.42%, respectively compared to the control sample. The Trivedi Effect®-Consciousness Energy Healing Treatment might have generated a new form of cefazolin sodium which would offer better solubility, dissolution rate, bioavailability, and thermal stability compared to the control sample. The Biofield Energy Treated cefazolin sodium would be very useful to design more efficacious pharmaceutical formulations that might offer better therapeutic response against urinary tract infections, respiratory tract infections, cellulitis, pneumonia, endocarditis, joint infection, biliary tract infections, blood infections, genital infections, and also prevent group B streptococcal disease at the time of delivery and before surgery, etc. 

             

Keywords: Complementary and Alternative Medicine, Cefazolin sodium, The Trivedi Effect®, Consciousness Energy Healing Treatment, Particle size, Surface area, DSC, TGA/DTG